Influence of Serum Albumin on HbA1c and HbA1c-Defined Glycemic Status: A Retrospective Study

Background: Glycated hemoglobin (HbA1c) is commonly used in the diagnosis and evaluation of glycemic control diabetes, it may be influenced by several non-glycemic factors, including albumin. This retrospective study investigated influence albumin on HbA1c HbA1c-defined status. Methods: The demographic, hematological, biochemical data were collected for 11,922 patients undergoing routine physical examination. Univariate multivariate linear regression analyses, stratified analyses interaction multiple logistic conducted to identify association between people with different Results: levels inversely associated serum level ( P < 0.0001) all participants. Risk factors leading included age > 45 years, high fasting plasma glucose (≥7.0 mmol/L), anemia. negative was curved had a threshold effect diabetic population; significantly stronger when fell below 41.4 g/L (β: −0.31, 95% CI: −0.45 −0.17, 0.0001). A 2 increase reduced odds dysglycemia, poor glycemia 12% 36%, after adjustment possible confounders. Conclusions: participants, diabetes (defined criteria). For lower level, there an increased risk erroneous HbA1c-based identification management